Theta Burst Stimulation of Human Cortex
نویسنده
چکیده
It has proved possible in experimental animals to manipulate synaptic efficiency using direct electrical stimulation of central nervous pathways. The introduction of transcranial methods of non-invasively stimulating the human brain raised hopes that similar effects could be produced in humans, with the potential for eventual therapeutic application in disease states. However, largely due to safety limitations, human subjects often require lengthy conditioning with repetitive transcranial magnetic stimulation (rTMS), and even then effects are often weak, variable and not beneficial in the therapeutic setting. In view of the difficulties, I have explored novel methods of conditioning the brain in conscious humans using rTMS which can swiftly produce powerful and controllable long-term changes in the excitability of cortical circuits. I have developed novel rTMS paradigms based on theta burst (TBS) patterns of neuronal firing occurring in the hippocampus of animals, which is an efficient way to produce long term potentiation in animal preparations. Very short (20 190 seconds) conditioning using different TBS patterns at low intensity (80% of active motor threshold) can safely produce controllable, consistent, long-lasting and powerful LTD and LTP-like effects on the motor system in conscious humans at an electrophysiological and behavioural level that outlast the period of stimulation by over an hour. In particular I have found that the pattern of delivery of TBS (continuous versus intermittent) is crucial in determining the direction of change in synaptic efficiency. I have therefore explored the mechanism of these effects and have found evidence for paired inhibitory and excitatory consequences of TBS that
منابع مشابه
Effects of theta-burst transcranial magnetic stimulation over the human motor cortex: A neuroimaging study
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تاریخ انتشار 2013